PI: Bahattin Koç, Supporting Agency: TÜBİTAK 1001, Duration: 2013-2015
The main aim of this project is to 3D bioprint live cell aggregates with biomaterials support structures in vascular tissue engineering. In addition, 3D bioprinting tool path planning and parameters are optimized based on the cell proliferation, morphology, autophagy and cell stress analyses. With this proposed work, the following novel methods will be developed: i) new computer aided algorithms will be developed to model and 3D print multi-cellular aggregates and their support structures with biomaterials (hydrogels),
ii) a novel multi-nozzle 3D bioprinter will be developed to fabricate the hybrid live cell support structures directly from the computer-aided design (CAD) models, iii) analyzing the biofabricated structures for cell aggregate fusion, cell morphology, autophagy and cell stresses, iv) optimizing 3D bioprinting topology (path planning) and bioprinting parameters. These novel ideas will advance the science and research in computer-aided tissue engineering.